Publications

Joshua S. Weinstock*, Maya M. Arce*, Jacob Freimer, Mineto Ota, Alexander Marson^, Alexis Battle^, Jonathan Pritchard^
2023-10-24 biorxiv

Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease

We mapped the gene regulatory network of key immune disease genes in primary CD4+ T cells using causal inference methods

DOI
Joshua S. Weinstock, Cecelia A Laurie, Jai G Broome, et al.
2023-04-26 Science Advances

The genetic determinants of recurrent somatic mutations in 43,693 blood genomes

We discovered thousands of unexpectedly common somatic mutations in blood

Code DOI
Joshua S. Weinstock*, Jayakrishan Gopakumar*, Bala Bharathi Burugla, Md Mesbah Uddin, …, Alexander G. Bick^, Siddhartha Jaiswal^
2023-04-01 Nature

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

We identified TCL1A as a key mediator of clonal expansion in CHIP clones

Code DOI
Jeffrey A. Goldstein*, Joshua S. Weinstock*, Lisa A. Bastarache, …, Matthew Zawistowski^
2020-11-11 PLOS Genetics

LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanks

We performed a GWAS meta-analysis of lab derived phenotypes from the Michigan Genomics Initiative (Umich) and BioVU (Vanderbilt)

DOI
Alexander G. Bick*, Joshua S. Weinstock*, Satish K Nandakumar, Charles P Fulco, …, Sekar Kathiresan^, Pradeep Natarajan^
2020-10-20 Nature

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

We discovered the genetic determinants of CHIP in ~97,000 TOPMed whole genomes

DOI